[Bluearrowll]

I know this won't sound like the best answer, but spread takes the least amoutn of effort and movement.

One hand - Well this is rather self explanatory to you
Index - You're moving 2 fingers over 4 arrows, and on harder songs this can be very hard for you
Spread - It's 4 fingers on 4 arrows (using 2 hands). all you need to do is press down on a key. Almost no movement other than this.

If you still wish to play Spread is the logical way to go. Though It's really up to you.